New Dissolution Method for Mesalamine Tablets and Capsules
نویسندگان
چکیده
منابع مشابه
New Dissolution Method for Mesalamine Tablets and Capsules
Dissolution methods are different for extended-release mesalamine capsules (pH 7.5 only) and delayed-release tablets (pH 1.4, 6.0, and 7.2). Mesalamine is used for the treatment of ulcerative colitis. The USP methods have several drawbacks in that they do not mimic gastrointestinal tract environments; tablets are removed from vessels to change dissolution medium; and neither method has been ado...
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PURPOSE This study describes the development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets using an HPLC method. METHOD The appropriate conditions were determinate after testing sink conditions, dissolution medium, and agitation intensity. The apparatus, paddle and basket, were applied to tablets and capsules, respectively. Fexofenadine hydroch...
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In this study, a discriminative dissolution method was developed for Cephalexin OD (orally disintegrating) tablets 750mg. The solubility and stability of the cephalexin API was determined in ten different solutions. In that 0.01N HCl, glycine buffer pH 3-0, acetate buffer pH 4.5 and water gave good stability and the solubility. Dissolution profiling of cephalexin OD tablets 750mg of single batc...
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Enrofloxacin is a fluoroquinolone for veterinary use; it has low aqueous solubility and relatively high permeability. Dissolution may be the limiting step in absorption for solid dosage forms having these characteristics. Considering this, in vitro dissolution tests are indicated to evaluate batch-to-batch quality and to support pharmaceutical equivalence studies. In this study, an alternative ...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2008
ISSN: 1521-298X
DOI: 10.14227/dt150308p7